Endocrine Abstracts

Introduction: The presence of diabetes-associated antibodies is an indicator of β-cell destruction. Our goal was to find out the prevalence of autoantibodies associated with the new onset of type 1 diabetes mellitus (DM1) without family history.Subjects and Methods: 22 patients (10 women and 12 men) with newly diagnosed DM1 no family history were examined. Average age of patients was 31.7±7.3 y.o., experience of DM1 was 2.3±0.8 months. All the...

The aim: To test cytotoxic effects of immune factors of patients with chronic diabetic foot ulcers on keratinocytes and fibroblasts in a 3D skin culture system.Materials and methods: In this study a multilayer 3D human skin model comprising of keratinocytes, fibroblasts and dendritic cells in an agarose-fibronectin gel was used. 20% serum of 13 patients with chronic noninfected diabetic foot ulcers, 13 diabetic type 2 patients and 13 healthy people and l...

Introduction: Preserving of C-peptide secretion in type 1 diabetes mellitus (DM1) is an important goal in treatment, as it provides the possibility of optimal compensation. Various approaches are used to achieve this goal. We initiated a study to assess the potential effect of the cell therapy based on autologous Tolerogenic Dendritic Cells on the newly diagnosed DM1 (NCT05207995, ClinicalTrials.gov).Methods: 4 patients who were injected with Tolerogenic...

Background: The problem of iodine deficiency in Belarus remains topical, due to the historical understanding of iodine deficiency in the environment and the negative impact of iodine deficiency on health. Strategy for elimination of iodine deficiency among the population was developed and implemented in the Republic of Belarus.Aims: To determine iodine sufficiency in children living in Belarus.Materials and methods: The study inclu...

Aim: To study the relationship of cytokines level in patients with diabetic foot syndrome (SDS) with a healing rate of ulcerative defect and diabetes compensation.Materials and methods: Twenty-four patients with DFS (DFS group) and 24 diabetic patients without foot ulcers (control group) (both groups comparable in age and other clinical and general laboratory characteristics, ongoing treatment, offloading mode). All DFS patients had chronic non-infected ...